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開催概要
開催回
第51回・2013年・京都
 

Caveolin-1 Genotypes Influence Prostate Cancer Susceptibility in Japanese Men

演題番号 : P65-1

[筆頭演者]
Satoru Sugie:1 
[共同演者]
Hiromasa Tsukino:1、Takenori Yamauchi:1、Shoichiro Mukai:1、Masato Fujii:2、Norihiko Shibata:2、Takahiro Akioka:2、Masafumi Nagano:2、Yoshiki Kuroda:1、Toshiyuki Kamoto:1

1:Miyazaki Univ., Japan、2:Fujimoto Hayasuzu Hosp., Japan

 

Objective:To evaluate the relationship between the Caveolin-1 T29107A polymorphism and the risk of prostate cancer(PC) among Japanese men, and the associations between CAV1 polymorphisms and clinicopathological characteristics.Material and Methods:We recruited 134 patients with PC and 86 healthy controls matched for age and smoking status. The CAV1 polymorphism status was determined by PCR-RFLP analysis.Results:Genotype distributions (p=0.0045) and allelic frequencies (p=0.0018) differed between PC and control groups in terms of the CAV1 polymorphism.Logistic regression analysis of case and control outcomes showed an odds ratio between the TT and AA polymorphisms of 0.35,indicating a reduced risk of PC to be associated with the AA polymorphism. Subset analysis revealed no significant associations between this polymorphism and clinicopathological characteristics of PC.Conclusion:The results of this study demonstrated a relationship between the CAV1 variant and risk of PC.

キーワード

臓器別:前立腺・男性生殖器

手法別:疫学・予防

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