演題抄録

International Session(Poster)

開催概要
開催回
第51回・2013年・京都
 

Heavy Metal Contamination of Ganges causing CA Gall Bladder in Gangetic plains

演題番号 : ISP-19

[筆頭演者]
Vikrant Singh Chauhan:1 
[共同演者]
Sudip Raina:1

1:Surgery, Metro Hospital,Faridabad, India

 

Background: Carcinoma of the gallbladder is the commonest malignancy of the biliary tract in the Indo Gangetic plains. Despite advances in imaging techniques carcinoma of the gallbladder remains a disease with poor prognosis with overall 5-year survival rate of about 5%.The etiological relationship of specific metals and their compounds to neoplasia has not seemed as important a field of investigation as that of a number of organic compounds, especially the volatile coal-tar products of industry.This is particularly significant in this era when the waters of the holy Ganges is being polluted like never before. Methods: The levels of Selenium, Zinc, Copper, Manganese, Cadmium, Chromium, Lead and Nickel in the present study were estimated in serum, bile and gallbladder tissue using atomic absorption spectrophotometer in thirty patients each of carcinoma of the gallbladder and cholelithiasis along with thirty age and sex matched healthy controls, presenting to the surgical unit of the University Hospital, Banaras Hindu University, Varanasi, India.Results: Selenium and Zinc levels were significantly reduced (p<0.001) in serum, bile and gallbladder tissue .Copper concentration was found to be significantly higher (p<0.001) in serum, bile and tissue of patients with carcinoma of the gallbladder. Lead, Cadmium, Chromium and Nickel levels were raised in serum and bile in carcinoma of the gallbladder.Conclusion: The present study has clearly demonstrated significant decrease in serum, biliary and tissue levels of selenium, zinc but increased copper, lead, cadmium chromium and nickel levels in patients with carcinoma of the gallbladder as compared to cholelithiasis and healthy controls.The waters of the mighty Ganges is being polluted by the heavy industries on its banks.This has particular significance for the millions of people using the waters of Ganges for routine purposes.This might have far reaching consequences in future.

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