演題抄録

International Session(Poster)

開催概要
開催回
第51回・2013年・京都
 

Intra-arterial cisplatin with concomitant radiation for hypopharyngeal cancer

演題番号 : ISP-9

[筆頭演者]
Kenichiro Nomura:1 
[共同演者]
Miki Takahara:1、Yuki Komabayashi:1、Seigo Ueda:1、Kan Kishibe:1、Isamu Kunibe:1、Akihiro Katada:1、Tatsuya Hayashi:1、Yasuaki Harabuchi:1

1:Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Japan

 

Objective: The current study evaluated the efficacy of radiation and concomitant high-dose superselective intra-arterial cisplatin infusion (RADPLAT) for patients with advanced hypopharyngeal cancer.
Study design: Retrospective, single-institutional study
Methods: Between February 2004 and October 2010, 43 patients with T2N0 or worse cancer were given superselective intra-arterial infusions of cisplatin (100 mg/m2 or 75 mg flat dose per week) with simultaneous intravenous infusions of thiosulfate to neutralize cisplatin toxicity and conventional external-beam radiotherapy (60-66 Gy).
Results: In total, 3, 7, 21, and 12 patients were diagnosed with stage II, III, IVA, and IVB cancer, respectively. During the median follow-up period of 34 months, the 3-year overall survival, disease-specific survival, and progression-free survival rates for all patients were 52.2%, 68.2%, and 56.1%, respectively. The 3-year local control and laryngoesophageal dysfunction-free survival rates were 81.6% and 49.4%, respectively. No patient died because of treatment toxicity. Among grade IV toxicity, cerebral infarction (n = 1) and laryngeal necrosis (n = 1) resulting in laryngectomy were observed.
Conclusion: Despite being a single-institution experience, the results of the current study suggest that RADPLAT can achieve favorable survival rates and high rates of laryngeal preservation for patients with advanced hypopharyngeal cancers.

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