演題抄録

International Session(Poster)

開催概要
開催回
第51回・2013年・京都
 

Antitumor effects of an herbal prescription JC001

演題番号 : ISP-3

[筆頭演者]
Ming-Shiou Jan:1,2 
[共同演者]
Shu-Han Chuang:1、You-Chain Lin:1、Meng-Hsien Chuang:3、Yu-Ying Lin:3、Yu-Pu Hsia:4、Jinghua Tsai Chang:3、Li-Jun Hsu:5

1:Institute of Microbiology and Immunology, Chung Shan Medical University, Taiwan、2:Division of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital, Taiwan、3:Institute of Medicine, Medical College, Chung Shan Medical University, Taiwan、4:Department of Microbiology and Immunology, Medical College, National Cheng Kung University, Taiwan、5:Department of Medical Laboratory Science and Biotechnology, Medical College, National Cheng Kung University, Taiwan

 

Immunity is an extremely important force against tumor development. Recently, many pharmaceutical companies have been developing anti-cancer drugs with immunity-modulating effects. However, the efficacy and safety of these bio-drugs need more evaluations. The advantages of our traditional medical prescriptions include their safeties confirmed by thousand years of clinical experiences, multiple therapeutic effects of different herbs on different targets, and comprehensive consideration of drug combinations for drug interactions. JC-001, a designed traditional herbal prescription, has been used as the liver-protecting medicine in Taiwan and China for decades. However, the effect of JC-001 on immune regulation is still unknown. Recently, we examined the immunoregulatory and anti-tumor activities of JC001in mice. Mice oral administration of JC001 for 8 weeks without tumor inoculation resulted in dose-dependent enhancements of the ratio of macrophages, especially the M1-type macrophages in spleen, and upregulation of the natural killer activity. After a low-dose T cell mitogen Con A stimulation, the degree of T cell proliferation was increased. We also found that with oral administration of JC001 after tumor inoculation, the tumor sizes formed in JC001-treated tumor-bearing BALB/c nu/nu mice were significantly larger than in JC001-treated tumor-bearing wild-type BALB/c mice. In addition, the immune cell infiltration and necrosis were significantly found in tumor obtained from JC001-treated tumor-burden mice. These results indicate that cell-mediated immunity, especially the activation of a T-cell mediated killing, plays a major role in the anti-tumor effects of JC001. Thus, JC001 may be efficacious for the prevention of cancer growth.

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