演題抄録

International Symposium

開催概要
開催回
第51回・2013年・京都
 

Clinical implications of plasma EBV DNA in early-stage NKTCL patients

演題番号 : IS3-6

[筆頭演者]
Ye-Xiong Li:1 
[共同演者]
Zhao-yang Wang:1、Qing-feng Liu:1、Hua Wang:1、Jing Jin:1、Wei-hu Wang:1、Shu-lian Wang:1、Yong-wen Song:1、Yue-ping Liu:1、Hui Fang:1、Hua Ren:1、Run-ye Wu:1、Bo Chen:1、Xi-mei Zhang:1、Ning-ning Lu:1

1:Dept. of Radiat. Oncol., Cancer Hosp., CAMS, China

 

The clinical value of plasma Epstein-Barr virus (EBV) DNA has not been evaluated in patients with early-stage extranodal nasal-type NK/T-cell lymphoma (NKTCL) receiving primary radiotherapy. Fifty-eight patients with stage I disease and 11 with stage II disease were recruited. High pretreatment EBV-DNA concentrations were associated with B-symptoms, elevated lactate dehydrogenase levels, and a high International Prognostic Indexscore. EBV-DNA levels significantly decreased after treatment. The 3-year overall survival (OS) rate was 82.6% for all patients. Stage I or II patients with a pretreatment EBV-DNA level of< 500 copies/mL had 3-year OS and progression-free survival (PFS) rates of 97.1% and 79.0%, respectively, compared with 66.3% (P .002) and 52.2% (P .045) in patients with EBV-DNA levels of> 500 copies/mL. The 3-year OS and PFS rates for patients with undetectable EBV-DNA after treatment was significantly higher than patients with detectable EBV-DNA (OS, 92.0% vs 69.8%, P .031; PFS, 77.5% vs 50.7%,P .028). Similar results were observed in stage I patients. EBV-DNA levels correlate with tumor load and a poorer prognosis in early-stage NKTCL. The circulating EBV-DNA level could serve both as a valuable biomarker of tumor load for the accurate classification of early-stage NKTCL and as a prognostic factor.

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