Clinicopathologic Features and Survival of Filipino Women with Triple-Negative Breast Cancers: A Single-Institution Experience
演題番号 : P-521
1:Division of Medical Oncology,Department of Medicine,University of the Philippines - Philippine General Hospital、2:Department of Internal Medicine, Perpetual Succour Hospital
Triple-negative breast cancers (TNBC) tend to have poor survival as compared to other immunohistochemical subtypes of breast malignancy. However, there has been no ample local data on survival of these patients in the Philippines.
Retrospective review of Filipino women with early TNBC (eTNBC) and metastatic TNBC (mTNBC) who were treated at Cebu Cancer Institute, Cebu, Philippines from January 1, 2005 to December 31, 2010 was done. Kaplan-Meier product limit estimate of survival was used to determine the survival rate. The impact of various clinicopathological and treatment factors on survival was assessed using Cox regression analysis.
Out of 237 Filipino women diagnosed with breast cancers, 24 (10.1%) had TNBC (median age of 49; 12 had eTNBC and 12 had mTNBC). Median follow-up was 60.9 months. Five-year overall survival (OS) was 32.9% for all TNBC (OS of 41.2% for eTNBC and 25.0% for mTNBC) while disease-free survival (DFS) was 35.4% for eTNBC. On univariate analysis, OS was related to menopausal status (p=0.049) and presence of lymphovascular invasion (LVI) (p=0.010) while DFS was related to LVI (p=0.029) and positive lymph nodes (p=0.035). On multivariate analysis, LVI was the only independent prognostic factors for both mortality and disease recurrence (p=0.050 and p=0.047, respectively).
Overall and disease-free survival rates of Filipino women with TNBC are about half of those reported by the Western counterpart. In addition, this study has shown that LVI was the only independent prognostic factor for mortality and disease recurrence in our study population.
Keywords: overall survival; triple-negative breast cancers; Filipino