演題抄録

ポスター

開催概要
開催回
第58回・2020年・京都
 

レゴラフェニブで治療した進行・再発結腸直腸癌患者におけるサルコペニアの影響

演題番号 : P-484

[筆頭演者]
村地 康:1 
[共同演者]
坂井 大介:1、小関 準:2、稲垣 千晶:1、西田 尚弘:1、山口 敏史:1、佐藤 太郎:1

1:大阪大学・先進癌薬物療法開発学寄附講座、2:名古屋大学・システム生物学分野

 

Background:
Regorafenib is a key agent for patients with advanced or recurrent colorectal cancer. Sarcopenia represented by skeletal muscle depletion is closely related to frailty and predicts oncological prognoses. We hypothesized that sarcopenia negatively affects the time to treatment failure (TTF) or overall survival (OS) of patients treated with regorafenib.
Methods:
We retrospectively reviewed the medical records of all patients treated with regorafenib between May 2013 and April 2019 at our institution. The cross-sectional area of the psoas muscle at the level of the third lumbar vertebra on baseline computed tomography (CT) was assessed to calculate the psoas muscle index (PMI). Sarcopenia was defined based on PMI cut-off values for Asian adults (6.36 cm2/m2 for males and 3.92 cm2/m2 for females).
Results:
Thirty-four patients were analyzed. The prevalence of sarcopenia was 44.1%. Sarcopenia was significantly associated with poorer OS (median, 5.1 vs. 9.0 months, p = 0.024). Less 75% 1M-RDI patients experienced significantly shorter TTF and OS than the rest, as did patients receiving total regorafenib dose of <3360 mg (median: 3.1 and 9.4 months, p < 0.001). Multivariate analysis showed that sarcopenia was a significant predictor of prognosis.
Conclusion:
Sarcopenia was a predictive marker of negative outcome for patients with advanced or recurrent colorectal cancer treated with regorafenib. Screening for sarcopenia can be used to identify patients more likely to benefit from regorafenib in routine clinical practice.

キーワード

臓器別:大腸・小腸

手法別:化学療法

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