演題抄録

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開催概要
開催回
第56回・2018年・横浜
 

子宮頸癌の広汎子宮全摘術後化学療法の有用性に関する検討―放射線治療と比較して―

演題番号 : P94-1

[筆頭演者]
演者)川口 龍二:1 
[共同演者]
棚瀬 康仁:1、小林 浩:1

1:奈良県立医科大学・産婦人科

 

Purpose: The purpose of this study was to examine the survival outcomes and adverse events of cervical cancer patients with intermediate- and high-risk groups who received systemic chemotherapy (CT group) as compared to those who received radiotherapy (RT group) after radical hysterectomy.
Method: This was retrospective study examining patients who underwent adjuvant therapy after radical hysterectomy for FIGO stage IB-IIB cervical cancer between 2006 and 2016. After radical hysterectomy, all patients received adjuvant CT or RT for intermediate- and high risk group based on the type of tumor factors.
Result: There were 94 patients eligible for this study. These included RT group (n=29, CCRT: 16, RT alone: 13) and CT group (n=65). Median follow-up time was 49.9 months (range 5.9-139.5 months). Sixty-three patients have squamous histology and 31 patients have non-squamous histology. Fifty-eigt patients underwent Taxane/Platinum regimen and 7 patients underwent other regimen in CT group. There were no significant differences in disease-free survival and overall survival between RT group and CT group (p=0.823, p=0.858). In CT group, 10 (58.8%) had local failure, 5 (29.4%) had distant failure, and 2 (11.8%) had combined failure. In RT group, 3 (33.3%) had local failure and 6 (66.7%) had distant failure.
There were no significant differences in the rate of recurrence (p=0.564) and recurrence patterns (p=0.236) between two group. The incidence of grade 3-4 non-hematolgic adverse events were more frequent in RT group (10/29; ileus 6, colitis 1, fistula 1, renal disorder 1, bone fracture) than CT group (4/65; neuropathy 3, ileus 1) (p<0.001). The incidence of grade 4 hematologic adverse events were more frequent in CT group than RT group (p<0.001).
Conclusion: Systemic chemotherapy may be as effective as radiotherapy in stage IB-IIB cervical cancer patients with intermediate-and high risk factors.

キーワード

臓器別:子宮

手法別:化学療法

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