演題抄録

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開催概要
開催回
第56回・2018年・横浜
 

本邦における食道神経内分泌細胞癌の検討

演題番号 : P70-8

[筆頭演者]
演者)菊池 由宣:1,2 
[共同演者]
山口 和久:1、島田 英昭:2、五十嵐 良典:1

1:東邦大学・消化器内科、2:東邦大学・臨床腫瘍学

 

[Background] Esophageal neuroendocrine carcinoma is rare tissue type of esophageal carcinoma. Therefore, there has been little study done concerning survival time and selected therapy. We reviewed case reports of esophageal neuroendocrine carcinoma in Japan. [Method] We identified a total 172 cases from 138 reports of esophageal neuroendocrine carcinoma using Japan Medical Abstracts Society. Among these, we analyzed 144 cases from reports that sufficient information on age, gender, clinical stage, therapy and survival time. [Result] The median survival time of Stage I and II/III was 25 months respectively, and there was no significant difference between both groups. On the other hand, the median survival time of Stage IV was 13 months. A significant (P = 0.02) difference was found between Stage I-III and Stage IV. In Stage II/III, the median survival time of surgery alone group, adjuvant group and neoadjuvant group were 12 months, 15 months and 25 months, respectively. The adjuvant group was significantly (P = 0.03) different from surgery alone. Similarly, the neoadjuvant group were significantly (P = 0.03) different from surgery alone. However, there was no significant difference between adjuvant group and neoadjuvant group (P = 0.87). In Stage IV, the median survival time of 5-FU plus platinum drugs (FP), CPT-11 plus Platinum drugs (CP) and VP-16 plus platinum drugs (EP) were 13 months, 15 months and 15 months, respectively. However, there were not significant difference in CP group (P = 0.42) and EP group (P = 0.83) against FP group. [Discussion] It was suggested that neoadjuvant chemotherapy was good prognosis as same as general esophageal carcinoma in Stage II/III. Although CP or EP group were not significant difference against FP group in Stage IV, the CP or EP group had long survival cases. Therefore, we consider that it should be select CP or EP in Stage IV.

キーワード

臓器別:食道

手法別:化学療法

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