演題番号 : P70-7
BACKGROUND & AIMS:
Esophageal adenocarcinoma in patients with short-segment Barrett's esophagus (SSBE) has been increased in Japanese population, however the risk factor about neoplastic progression in SSBE have not been identified clearly.
The aims of this study was to examine about pathophysiological characteristics of patients with or without adenocarcinoma in SSBE, and to find the risk factors associated with development of neoplasia in SSBE.
Thirty-seven patients (29 males, median age 68 years) with Barrett's adenocarcinoma (BAC) in SSBE and 72 patients (44 males, median age 66 years) without BAC in SSBE were compared. Endoscopic findings (hiatus hernia, visibility of palisade vessels, positivity of mucosal break, positivity of gastritis), body mass index (BMI), cholesterol and Hemoglobin A1c (HbA1c) levels, drinking and smoking were evaluated. Endoscopic findings were evaluated by two expert endoscopists.
The mean cholesterol levels in patients with BAC were significantly higher than the patients without BAC (217.1±7.5 mg/dl vs. 193.8±5.6 mg/dl, P = 0.0142). Also the mean HbA1c levels in patients with BAC was significantly higher than the patients without BAC (6.1±0.1% vs. 5.7±0.1%, P = 0.0254). There was a tendency for the positive rate of atrophic gastritis to be lower in patients with BAC (with BAC 29.7% vs. without BAC 48.6%, P = 0.0679). The other factors were not different between two groups.
Neoplastic progression in SSBE was associated with hypercholesterolemia and high HbA1c levels. More detailed examination should be done about the relation between these factors and tumor progression in SSBE.