演題番号 : P30-2
A treatment-related myelodysplastic syndrome (MDS) or a treatment-related leukemia is known to be rare and has a poor prognose. Here we report two cases of treatment-related leukemia with literature reviews.
A patient of mid-50 years of age was diagnosed with an ovarian cancer FIGO stage 3C. She underwent 3 surgeries and received multiple regimens of chemotherapy in several years from the first treatment. The received regimen of the chemotherapy was included platinum, taxane and topoisomerase inhibitor. After several years of the initial treatment, she presented with fever and abnormal hemogram. She went through bone marrow aspiration and was diagnosed with treatment-related MDS. Therefore Azacitidine was started. She is now mainly having supportive therapy.
A patient of mid-50 years of age was diagnosed with a cervical cancer FIGO stage 2B. She achieved complete response to concurrent chemoradiotherapy. During the investigation of acute cholecystitis, her lab tests showed thrombocytopenia and abnormal hemogram. She was diagnosed as having treatment-related leukemia from the result of bone marrow aspiration. After the diagnosis she has achieved complete response to induction of the remission therapy.
Treatment-related MDS or leukemia is a rare disease. Patients going through and after the chemotherapy should be followed by close observation with constant blood test including peripheral blood smear examination.