演題抄録

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開催概要
開催回
第56回・2018年・横浜
 

2ndラインでラムシルマブを使用しネフローゼ症候群を呈したS状結腸癌の1例

演題番号 : P18-5

[筆頭演者]
演者)進藤 吉明:1 
[共同演者]
櫻庭 一馬:1、齋藤 由理:1

1:中通総合病院・消化器外科

 

Aflibercept and Ramucirumab could be used now for metastatic colorectal cancer. The order of the use about Aflibercept and Ramucirumab is unclear.We'll report a case of Sigmoid colon cancer which became nephrose syndrome in 2nd line chemotherapy with ramucirumab after Bavacizumab use.Case : 61years old Male; It was diagnosed as perforated sigmoid colon cancer and multiple Liver metastasis in 20XX. Hartmann operation was carried out. 15 courses of XELOX+ Bevacizumab (Bmab) chemoptherapy was carried out to a liver metastasis.High blood pressure was controlled by a hypotensive drug. Albuminuria was changing in 1+.The tumor size increased again. The chemotherapy was changed to FOLFIRI + Ramucirumab treatment.A course of edema of the whole body was admitted about 2 weeks later after prescription, and there was also more than 8 kg of increase of body weight and come to our hospital. Albuminuria was 4+. I diagnosed nephrotic syndrome and entered. After that the state of the whole body was quiet 3 months later. Hepatectomy was considered. A multiple bone metastasis was revealed by preoperative bone sintigraphiy. The whole body state was quiet and chemotherapy was resumed about 3 months later. 14 courses of FOLFIRI+Cetuximab chemotherapy was carried out. Albuminuria was changing from 2+ to 3+, but I gave priority to chemotherapy. A rise of a tumor marker and a rise with the tumor size were admitted again after that. TFTD is being begun and treated at present.Albuminuria still continues and is obstruction of treatment.
We have that 3 drugs with Bevacizumab (BBP) and Afliberscept, Ramucirumab about use of a VEGF antibody after Bmab use.It's still unclear which you'd like out of 3. Drugs. Anticancer drug prescription isn't done any more for 3 months by a cause of nephrotic syndrome this time. We had an influence bad for treatment. I'd like to expect 3 a clear index of 3 drugs how to use them appropriately from now on.

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臓器別:大腸・小腸

手法別:化学療法

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