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開催概要
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第56回・2018年・横浜
 

大腸癌肝転移患者の化学療法前後での腸腰筋面積測定の有用性

演題番号 : P17-7

[筆頭演者]
演者)福岡 達成:1 
[共同演者]
前田 清:1、永原 央:1、渋谷 雅常:1、井関 康仁:1、松谷 愼治:1、山添 定明:1、木村 健二郎:1、豊川 貴弘:1、天野 良亮:1、田中 浩明:1、六車 一哉:1、八代 正和:1、平川 弘聖:1、大平 雅一:1

1:大阪市立大学・腫瘍外科

 

Introduction: recently, sarcopenia influences the prognosis of several cancers. Catabolic changes and the progression of poor nutrition are considered to be important factors in the development of sarcopenia. The aim of the present study was to investigate the correlation between the change in the psoas muscle index during systemic chemotherapy and the prognosis of patients with colorectal liver metastasis.
Materials and Methods: fifty one patients who underwent systemic chemotherapy for colorectal liver metastasis were enrolled in the present study. We calculated the psoas muscle index (PMI) at the time before and after systemic chemotherapy using the following formula: psoas muscle area (cm2) / the square of the body height (m2) at the level of navel on computed tomography images. The change of the PMI before and after chemotherapy was calculated. We evaluated the relationship between the prognosis and clinicopathological factors, including the prognostic value of a change in the PMI value.
Results: A >5% decrease in the PMI value during chemotherapy was observed in 27 of the 51 patients. Disease control rate (87.5%) in the patients with a ≦5% decrease in their PMI values was higher than that (64%) in the patients with a >5% decrease in the PMI value. Kaplan-Meier survival curves and a log-rank test revealed that a >5% decrease in the PMI value was associated with shorter overall survival and progression free survival in comparison to patients who did not show a >5% decrease in their PMI value.
Conclusion: in the present study, we revealed that the decrease in the PMI after systemic chemotherapy might predict a poor prognosis in colorectal liver metastasis.

キーワード

臓器別:大腸・小腸

手法別:化学療法

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