演題抄録

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開催概要
開催回
第56回・2018年・横浜
 

肝切除を伴う肝門部胆管癌患者の術後好酸球と予後の関係

演題番号 : O36-2

[筆頭演者]
演者)新毛 豪:1 
[共同演者]
野田 剛広:1、江口 英利:1、岩上 佳史:1、山田 大作:1,2、秋田 裕史:1、浅岡 忠史:1、後藤 邦仁:1、小林 省吾:1、土岐 祐一郎:1、森 正樹:1

1:大阪大学・消化器外科、2:大阪国際がんセンター・消化器外科

 

Background/Aims: Hilar cholangiocarcinoma (H-CCA) is a lethal neoplasm. It is important to identify factors relating to the patients' prognosis. Several studies demonstrated that postoperative immune-response were associated with prognosis for patients with various malignant tumors. Whether perioperative increases in eosinophils leads patients' prognosis or not still remains controversial. In this study, we focused on the postoperative peak values of eosinophils for H-CCA and examined the surgical outcomes.
Materials and Methods: Twenty-six patients received curative resection for H-CCA. Twenty-five patients underwent hepatic resection and one patient underwent only bile duct resection. The patients with hepatic resection were included for this study and were investigated on following factors; clinical features of patients, tumor factors, surgical outcomes and long-term prognosis.
Results: The patients were 19 males and 6 females, and mean age was 67.3 years old. The tumor locations were Bl (n=8), Br (n=6) and Bp (n=11). The mean tumor size was 27 mm. All patients received the hemihepatectomy, the resection of caudal lobe and choledochojejeunostomy. The T factors were following; T1(n=4), T2(n=13), T3(n=5) and T4(n=3). The N factors were following; N0 (n=17) and N1(n=8). The final stages were following; Stage I(n=5), II(n=11), III(n=6) and IV(n=4). The peak numbers of eosinophils (/ul) ranged from 61 to 1992 with median value of 375. Overall survival rate of 5-year was 43.1% and disease-free survival rate of 5-year was 31.1%. The patients were divided into 2 groups according to the median value of eosinophils. The patients of high eosinophils group showed more favorable prognosis compared with those of low eosinophils group (5-year overall survival rates; 57% vs 23%, p=0.0457).
Conclusions: The postoperative peak values of eosinophils in H-CCA with hepatectomy might be a prognostic factor for patients' survival.

キーワード

臓器別:胆嚢・胆道

手法別:バイオマーカー

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