演題抄録

FACO Poster Session

開催概要
開催回
第56回・2018年・横浜
 

The study of lymphatic drainage pattern of internal mammary sentinel lymph node in breast

演題番号 : FP1-5

[筆頭演者]
Speaker)Xiaoshan Cao:1 
[共同演者]
Binbin Cong:1、Yongsheng Wang:1

1:Breast Cancer Center, Shandong Cancer Hospital Affiliated to Shandong University, China

 

Purpose: To detect the lymphatic drainage pattern of internal mammary area and verify the concept of internal mammary sentinel lymph node (IM-SLN) in breast.
Materials and Methods: A small particle radiotracer (99mTc-Dextran 40) was prepared and tested. 99mTc-Dextran 40 was injected into intraparenchyma at the sound breast by a modified radiotracer injection technique. Subsequently, dynamic SPECT, CT, and SPECT/CT combination images were performed to identify the radioactive lymph vessels and internal mammary lymph node (IMLNs). The direction of lymph drainage and the location of the IMLNs were identified in the SPECT/CT imaging.
Results: The radiochemical purity of 99mTc-Dextran 40 was >95%. 99mTc-Dextran 40 could drainage into 1st, 2nd, and 3rd lymph node and the radioactive lymph node could be detected by the γ detector in the animal experiment. After 99mTc-Dextran 40 injecting into intraparenchyma, 50.0% (15/30) cases were identified the drainage lymphatic vessels and radioactive IMLNs by SPECT. The drainage lymphatic vessel was found from injection point to the 1st IMLN (IM-SLN) after 10.5±0.35 min radiotracer injection, and then 99mTc-Dextran 40 was accumulated into the IM-SLN. The combination imaging of SPECT/CT showed the 2nd IMLN received the lymph drainage from the IM-SLN. The lymphatic drainage was step by step in the internal mammary area.
Conclusion: The lymph was identified to drain from different regions of the breast to IM-SLN, and then outward from IM-SLN to other IMLN consecutively. It demonstrated the concept of the IM-SLN and provided more evidences for the application of internal mammary sentinel lymph node biopsy.

キーワード

臓器別:Breast

手法別:Imaging

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