演題抄録

一般演題 (示説)

開催概要
開催回
第54回・2016年・横浜
 

Risk factors for the loss of lean body mass after gastrectomy for gastric cancer

演題番号 : P6-6

[筆頭演者]
青山 徹:1 
[共同演者]
前澤 幸男:1、神尾 一樹:1,2、瀬上 顕貴:1,2、藤川 寛人:2、林 勉:2、山田 貴允:1,2、尾形 高士:1、長 晴彦:1、佐藤 勉:2、大島 貴:2、湯川 寛夫:2、利野 靖:2、益田 宗孝:2、吉川 貴己:1,2

1:地方独立行政法人神奈川県立病院機構神奈川県立がんセンター・外科、2:横浜市立大学・医学部・外科治療学

 

Background & Aims: Lean body mass loss, which affect for chemotherapy continuation, is frequently observed in gastric cancer patients who underwent gastrectomy for gastric cancer. However, the risk factors of Lean body mass loss after gastrectomy remain unclear. Methods: The present study retrospectively examined the patients who underwent curative gastrectomy for gastric cancer between June 2010 and March 2014 at Kanagawa Cancer Center. All patients received peri-operative care of the enhanced recovery after surgery protocol. % Lean body mass was calculated by percentile of lean body mass at one month after surgery to preoperative lean body mass. Severe lean body mass was defined as % lean body mass over 5%. Risk factors for severe lean body mass were determined by both univariate and multivariate logistic regression analyses. Results: Four-hundred eighty five patients were examined. Median age was 67 years. Operative procedure was total gastrectomy in 190 patients and distal gastrectomy in 295 patients. Surgical complications of grade 2 or more defined by Clavien-Dindo classification was observed in 78 patients including pancreatic fistula in 19, anastomotic leakage in 11 and abdominal abscess in 7. There was one mortality patient. Both univariate and multivariate logistic analyses demonstrated that surgical complications (odds rate 3.576, p=0.001), and total gastrectomy (odds rate 2.522, p=0.0001), and gender (odds rate 1.928, p=0.001) were significant risk factors for severe lean body mass. Conclusions: Surgical complications and total gastrectomy were significant risk factors for 5% of lean body mass loss at first month after gastrectomy. To maintain lean body mass after gastrectomy, the physician need to careful attention for the patients who had these risk factors.

キーワード

臓器別:胃・十二指腸

手法別:集学的治療

前へ戻る