演題抄録

一般演題 (示説)

開催概要
開催回
第54回・2016年・横浜
 

Oral glutamine supplementation in prevention of radiotherapy-induced esophagitis in advanced non-small cell lung cancer patients

演題番号 : P25-4

[筆頭演者]
Chang Chang Yu:1 
[共同演者]
Chang Shih-chieh:1

1:Far Eastern Memorial Hospital, New Taipei City, Taiwan・Internal Medicine・Chest Medicine

 

Background
Complications related to concurrent chemoradiotherapy (CCRT) such as acute radiation-induced esophagitis (ARIE) may cause significant morbidity and unplanned treatment delays in patients with advanced non-small cell lung cancer (NSCLC). We designed a prospective randomized study to assess the impact of Glutamine supplementation in preventing CCRT-induced toxicities of advanced NSCLC patients.

Methods
Thirty patients diagnosed with NSCLC were included to the study. Fifteen patients (50%) received prophylactic powdered GLN orally at a dose of 10g/8h. The prescribed radiation dose to the planning target volume was 30 Gy in 2-Gy fractions. The endpoints were radiation-induced esophagitis, mucositis and body weight loss.

Results
At a median follow-up of 18.4 months (range 8.4-28.2), all patients tolerated GLN well. Administration of GLN was associated with a decrease in the incidence of grade 2 or 3 ARIE (6.7% vs. 53.4% for Gln+ vs. Gln-; p=0.004). GLN supplementation appeared to significantly delay ARIE onset for 5 days (18 days vs.12 days; p=0.027) and reduced incidence of weight loss (20% vs. 73.3%; p=0.01).

Conclusion
Our study suggests a beneficial effect of oral glutamine supplementation for the prevention from radiation-induced injury and body weight loss in advanced NSCLC patients who receiving CCRT.

キーワード

臓器別:肺・縦隔・胸膜

手法別:臨床試験

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