演題抄録

FACO/JSCO Joint Symposium

開催概要
開催回
第54回・2016年・横浜
 

乳癌トライアルの提案

演題番号 : FAJS-5

[筆頭演者]
井本 滋:1 

1:杏林大学・医学部付属病院・外科(乳腺)

 

Breast cancer is treated with surgery, medicine and radiation on the basis of patient and tumor background. Some early breast patients have disseminated cancer cells in bone marrow and blood as well as advanced patients. Recent technology can detect circulating tumor cells and cell-free DNA in blood from cancer patients. When these biomarkers of liquid biopsy are positive in patients, early relapse or disease progression will be observed. On the other hand, some recurrent breast cancer is diagnosed several years or more after initial treatment of primary disease and also tends to be slowly progressive. Such an indolent disease, especially oligometastatic recurrence, is often managed with combination of loco-regional treatment and systemic treatment. It is not clear understood why delayed recurrence occurs under the circumstances of dormant cancer cells in patients. However, from our experience, delayed and oligometastatic recurrence seems to be curable with appropriate combined treatment. To investigate efficacy of loco-regional and systemic treatment in delayed and oligometastatic recurrence of breast cancer, a registration trial in FACO is being planned. It is considered as the second trial in FACO next to CONVO-GC-1. Trial concept and related issues will be discussed.

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