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開催概要
開催回
第53回・2015年・京都
 

前立腺がんにおけるP53変異予測発現プロファイルの予後予測の有用性

演題番号 : WS19-1

[筆頭演者]
山口 茂夫:1 
[共同演者]
高橋 信:4、茂櫛 薫:2、今井 美沙:3、影山 俊一郎:1、三浦 佳代:1、石岡 千加史:4、加藤 俊介:1

1:順天堂大学腫瘍内科、2:順天堂大学大学院医学研究科ゲノム再生医療センター、3:順天堂大学大学院医学研究科先端的がん治療開発センター、4:東北大学医学部腫瘍内科

 

Background: In many cancers, structurally mutation of TP53 is frequently observed, but prognosis of the patients with TP53 mutation is controversial. We have reported that expression profile of 33 genes, which predicts TP53 mutation status (TP53 signature), has the ability to predict overall survival and recurrence after surgery in breast cancer (Cancer Sci,2008) and also the efficacy of NAC and recurrence after surgery in breast cancer (O1-15-2, JSMO 2014). The aim of this study is to determine whether the TP53 signature can also predict overall survival of early prostate cancer.
Materials and Method: A public microarray data set, which contained resectable prostate cancer of 70 patients (Cancer Cell, 2010.), is obtained from Oncomine. Of 70 patients, we used 61 patients' data, which follow up time is over 5 years. We classified these patients into two groups using TP53 signature by hieratical clustering method.
Result: 28 percent (18 of 61) of patients is determined as mutant type of TP53 signature. There is no statistically significant difference in clinical stage and gleason score between mutant type and wild type of TP53 signature. Regardless of gleason score, patients in mutant type of TP53 signature groups showed significantly worse prognosis in recurrence free survival than patients in wild type TP53 signature groups (p<0.05). Patients whose gleason score is over 7 and TP53 mutant signature type are extremely worse prognosis in progression free survival compareing to other patients (p<0.05).
Conclusion: The expression signature of TP53 has the ability to predict prognosis of resectable prostate cancer. Our data suggests that prostate cancer patients with mutant type of TP53 signature group may need careful observation and more intensive adjuvant therapy after operation.

キーワード

臓器別:前立腺・男性生殖器

手法別:バイオマーカー

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