演題番号 : WS100-3
Hyponatremia is very popular complication with hospitalized patients. In malignancies, hyponatremia sometime lead to poor prognosis. So we investigated hyponatremia patients in non-Hodgkin's lymphoma follicular lymphoma (NHL FL).
[Material and Methods]
The subjects in this study were 58 patients who were treated with combination chemotherapy including rituximab who were histopathologically diagnosed as having non-Hodgkin's lymphoma follicular lymphoma (NHL FL) from January 2003 to December 2012. Criteria of hyponatremia is evaluated in accordance with the National Cancer Institute Common Terminology Criteria for adverse Events (version 3.0). Survival curves and the median survival times were estimated by the Kaplan-Meier method and any significant differences between the two groups were evaluated by the Log rank test. This study was reviewed and approved by the institutional ethics committee of Toho University Medical Center Omori Hospital on May 8, 2014 (Review No. 25-9). The authors and coauthors have no conflict of interest to disclose.
All cases were 58 cases, eligible cases were 52 cases. Hyponatremia cases were 28 cases (53.8%) including Grade1 were 22 cases, Grade3 were 5 cases and Grade4 were 1 cases. About clinical stage by Ann Arbor classification, stageI not exist, II were 7 cases including hyponatremia was 4 cases (57.4%), III were 14cases and 9 cases (64.3%), IV were 31 cases and 14 cases (45.2%).
About complete response rate (CRR), normal serum Na level group was 91.7%, hyponatremia group was 75 %,About overall survival, 2 groups did not reached median survival time and there was not significant differences between 2 groups. 5 years overall survival (OS) rate were normal group was 82.5%, hyponatremia group was 85.6%.
Our study indicated that hyponatremia in follicular lymphoma led to low CRR.