演題抄録

一般演題 (示説)

開催概要
開催回
第53回・2015年・京都
 

Loss of lean body mass as an independent risk factor for continuation of S-1 adjuvant chemotherapy for gastric cancer

演題番号 : P52-8

[筆頭演者]
Aoyama Toru:1,2 
[共同演者]
Kawabe Taiichi:2、Fujikawa Hirohito:2、Hayashi Tsutomu:2、Yamada Takanobu:2、Sato Tsutomu:1,2、Ogata Takashi:1、Cho Haruhiko:1、Yamamoto Naoto:2、Oshima Takashi:2、Yukawa Norio:2、Morinaga Soichiro:1、Rino Yasushi:2、Masuda Munetaka:2、Yoshikawa Takaki:1,2

1:Gastrointestinal Surgery, Kanagawa Cancer Center、2:Department of Surgery, Yokohama City University

 

Background & Aims: Compliance with S-1 adjuvant chemotherapy is often poor. The aim of the present study was to clarify risk factors for the continuation of S-1 after gastrectomy. Methods: This retrospective study selected patients who underwent curative D2 surgery for gastric cancer, were diagnosed with stage II/III disease, had a creatinine clearance > 60 ml/min, and received adjuvant S-1 at our institution between June 2010 and March 2014. The time to S-1 treatment failure (TTF) was calculated. Results: Fifty-eight patients were selected for the present study. When the TTF curves stratified by each clinical factor were compared by the log-rank test, lean body mass loss (LBL) of 5% was regarded as a critical cut-off point. Both uni- and multivariate Cox's proportional hazard analyses demonstrated that LWL was a significant independent risk factor for continuation. The six-month continuation rate was 91.7% in the patients with a LBL < 5%, and 66.3% for patients with a LBL > 5% (P=0.031). Conclusions: LBL was the most important risk factor for a decrease in compliance to adjuvant chemotherapy with S-1 in the patients with stage II/III gastric cancer who underwent D2 gastrectomy. To improve drug compliance, which would improve survival; it is a key to maintain the lean body mass before starting S-1 adjuvant treatment. Our study emphasizes the requirement for adequate studies of perioperative nutritional intervention in patients who receive gastrectomy for advanced gastric cancer.

キーワード

臓器別:胃・十二指腸

手法別:トランスレーショナルリサーチ

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