演題抄録

International Symposium

開催概要
開催回
第53回・2015年・京都
 

Oncofertility: The Preservation of Fertility Options for Young People with Cancer

演題番号 : IS1-1

[筆頭演者]
Woodruff Teresa K.:1 

1:Feinberg School of Medicine, Department of Obstetrics & Gynecology, Northwestern University, USA

 

Cancer is now a disease with a variety of treatment options, which are leading to longer and more productive lives by survivors. Globally, there are 14 million people diagnosed with cancer. 10% of these newly diagnosed men and women are under the age of 45 years old. Infertility can be a consequence of many of the more aggressive chemo- and radiation therapies that prolong and save lives. The ability to easily preserve sperm prior to cancer treatment provides hope at the time of diagnosis and families later in life for male survivors. Unlike sperm, the female germ cell, the oocyte or egg must be retrieved surgically. Moreover, the vast majority of collected oocytes will be immature and cannot be used immediately by a woman who is ready to start a family. The overall hypothesis of the program is that effective fertility-extending options can be provided to young women undergoing life-preserving cancer treatment. The purpose of our work is to bring physicians, medical ethicists, social scientists and basic scientists together to develop new strategies for fertility preservation for female cancer survivors under the new discipline of oncofertility. At the basic science level, complex issues of ovarian function and preservation must be addressed including the problem of follicle growth and development in vitro. Using a tissue-engineered approach, we have developed an in vitro follicle growth system that supports the maturation of the enclosed oocyte, which can be fertilized and results in live, healthy and reproductively competent mice. The goal of our program and the broader Oncofertility Consortium is to explore and expand the reproductive options available to young people facing a fertility-threatening but life-preserving cancer treatment. This work was supported by the Center for Reproductive Health After Disease, P50HD076188 from the National Institutes of Health NCTRI and the Oncofertility Consortium, UL1DE019587 and RL1HD058295.

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