演題抄録

FACO International Workshop

開催概要
開催回
第53回・2015年・京都
 

Identification of the predictor for gastric cancer recurrence using lectin microarray method

演題番号 : FWS7-5

[筆頭演者]
Futsukaichi Takuro:1 
[共同演者]
Etoh Tsuyoshi:1、Nakajima Kentaro:1、Ichimanda Michihiro:1、Enpuku Shinichiro:1、Hiratsuka Takahiro:1、Akagi Tomonori:1、Tajima Masaaki:1、Shibata Tomotaka:1、Ueda Yoshitake:1、Tojigamori Manabu:1、Shiroshita Hidefumi:1、Shiraishi Norio:1、Inomata Masafumi:1

1:Gastroenterological and Pediatric Surgery,, Hospital, Oita University

 

Abstract
Purpose: Molecular markers are urgently required as indicators for gastric cancer recurrence. The aim of this study was to identify lectins that can be used to predict gastric cancer recurrence after gastrectomy.
Methods: We determined lectin expression profiles by lectin microarray analysis in 60 patients with gastric cancer underwent curative gastrectomy at the Oita University Hospital. Patients with and without gastric cancer recurrence were compared in terms of lectin expression by univariate and multivariate analyses.
Results Thirteen lectins showed a significant increase in binding to cancer tissues, whereas 11 lectins showed a significant decrease in binding to cancer tissues when compared with binding to normal epithelia. A multivariate analysis revealed that lymph node metastasis and low Bauhinia purpurea lectin (BPL)-binding signals were independent predictive factors for recurrence. All patients with low BPL expression had significantly worse relapse-free survival than those with high BPL expression.
Conclusions To the best of our knowledge, our results provide the first evidence that BPL expression is a predictor of gastric cancer recurrence using a novel lectin microarray system.

キーワード

臓器別:胃・十二指腸

手法別:トランスレーショナルリサーチ

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