演題抄録

FACO International Workshop

開催概要
開催回
第53回・2015年・京都
 

Prognosis and recurrent patterns in patients of advanced gastric cancer treated with neoadjuvant chemoradiotherapy

演題番号 : FWS7-4

[筆頭演者]
Yura Masahiro:1 
[共同演者]
Takahashi Tsunehiro:1、Nakamura Rieko:1、Wada Norihito:1、Kawakubo Hirofumi:1、Takeuchi Hiroya:1、Kitagawa Yuko:1

1:Department of Surgery, School of Medicine, Keio University

 

Background:
Because of curative surgery is regarded as the only option for cure in patients with highly advanced gastric cancer, the prognosis still remains unfavorable. We previously reported phase I studies of neoadjvant chemoradiotherapy (CRT) of S-1 plus cisplatin to improve the prognosis of advanced cases. In this study, we examined the prognosis and recurrent sites of patients in these studies.
Methods:
Between March 2010 and July 2012, 22 patients were entered to these trials. After neoadjuvant treatment of CRT, a curative gastrectomy with extended (D2) lymph node dissection was planned.
Results:
Twenty-two patients (cStageIIIA / IIIB / IV : 8/11/3) were enrolled into this analysis and 18 patients were performed gastrectomy after neoadjuvant CRT. Three patients refused surgical treatment and 1 patient was performed gastro-jejunum bypass because of cancer invasion to the duodenum, transverse colon and pancreas. 14 of 18 patients who underwent gastric surgery showed a histological response to CRT (grade 1b or more effective), including 3 patients with a pathological complete response (grade 3).
The 3-year disease free survival rate of gastrectomy group was 55.6% and 3-year overall survival rate was 88.9%. The 3-year overall survival rate of all patients was 90.4%. Nine of 18 patients who were treated with surgical treatment had the recurrence event. Five patients were the peritoneum dissemination and 4 patients were distant lymph node metastasis.
Conclusion:
Of 14 (77.8%) patients showed histological response to CRT. In addition, this study showed favorable prognosis of cases with advanced gastric cancer. Neoadjvant CRT might expected as a precious strategy for advanced gastric cancer.

キーワード

臓器別:胃・十二指腸

手法別:臨床試験

前へ戻る