演題抄録

FACO International Workshop

開催概要
開催回
第53回・2015年・京都
 

Risk factors, clinical features, and prognosis after hepatectomy for centrally located hepatocellular carcinoma

演題番号 : FWS4-1

[筆頭演者]
Fei Tian:1 
[共同演者]
Jianxiong Wu:1

1:Abdominal Department, Peking Union Medical College,Cancer Hospital

 

BACKGROUND: Reports on the clinical features and prognosis of patients after liver resection for centrally located hepatocellular carcinoma (cHCC) are lacking. This study aimed to clarify the risk factors for recurrence and overall survival (OS) of cHCC in a cohort of Chinese patients.
METHODS: We retrospectively reviewed the data from 214 patients who underwent hepatectomies for cHCC in Chinese National Cancer Center from January 2006 to August 2013. We divided patients into three subgroups according to disease free survival(DFS): high risk (2 years), mid risk (2 years-5 years), and low risk (5 years). Clinicopathological characteristics were compared and prognostic factors were evaluated using univariate and multivariate analyses.
RESULTS: Among the 214 cases, 97 patients were enrolled in high risk group, 65 in mid risk group, and 52 in low risk group. The median DFS for high risk group was 14.0 (6.8-23.2) months compared to 29.0 (25.7-59.0) months for mid risk group and 67.5 (60.9-91.6) months for low risk group (P = 0.009). Multivariate analysis among high risk, mid risk and low risk groups demonstrated that tumor size > 50 mm, presence of microvascular invasion, and preoperative TACE were poor prognostic factors for DFS, while alfa-fetoprotein <200 ng/mL and steatosis were favorable prognostic factors. 88.1% patients of high risk group had all the three risk factors, the percentage was 56.7% in mid risk group and 32.1% in low risk group respectively. In addition, high risk group was correlated with a significantly higher incidence of tumors adjacent (<1cm) to the inferior vena cava compared with the other two groups (38.1 vs. 23.7 and 76%, p=0.021).
Conclusions: Tumor size > 50 mm, presence of microvascular invasion, and preoperative TACE were associated with poor survival. A prognostic model containing these factors may provide accurate prediction of survival or risk stratification, and patients with these risk factors should be candidates for adjuvant therapy.

キーワード

臓器別:Liver

手法別:Clinical Trial

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