演題抄録

FACO International Workshop

開催概要
開催回
第53回・2015年・京都
 

Epithelial paradox: Clinical significance of co-expression of E-cadherin and vimentin in invasive breast cancer

演題番号 : FWS11-1

[筆頭演者]
Yamashita Nami:1 
[共同演者]
Tokunaga Eriko:2、Inoue Yuka:3、Tanaka Kimihiro:3、Ueo Hiroki:3、Saeki Hiroshi:3、Oki Eiji:3、Maehara Yoshihiko:3

1:Dept of Comprehensive Clinical Oncology, Graduate School, Kyushu University、2:Dept of Breast Oncology, National Hospital Organization Kyushu Cancer Center、3:Dept of Surgery and Science, Graduate School, Kyushu University

 

Background: E-cadherin and vimentin are now regarded as major and conventional canonical markers of epithelial-mesenchymal transition (EMT). It is commonly assumed E-cadherin is uniformly lost during the process of EMT, however, the role of E-cadherin in breast cancer biology is still unclear and more complex. Although, cell cohesion during breast cancer invasion is often overlooked, accumulating evidences indicate that breast tumor cells are typically cohesive and often display membrane-localized E-cadherin in both the primary tumor and distant metastases, termed collective invasion. Multiple mechanisms have emerged to address how epithelial breast tumors invade. Aims: The aim of this study is to reveal the clinical importance of the expression of E-cadherin and vimentin in breast cancer. Patients and Methods: The E-cadherin and vimentin expression were evaluated by immunohistochemistry in 177 invasive breast cancer samples. Among these, E-cadherin and vimentin expression were evaluated in the set of primary breast cancer and metastatic lymph nodes in 65 cases. Results: The positive vimentin expression was highly correlated with poor DFS and overall survival OS (p=0.019 and p=0.0044), however, the E-cadherin expression alone did not correlate with prognosis. Interestingly, Both E-cadherin and vimentin positive tumor had the worst DFS and OS among all breast cancer (p=0.03 and p=0.0089). Vimentin expression was highly correlated between primary tumors and metastatic lymph nodes. E-cadherin expression levels were significantly elevated in metastatic lymph nodes (p=0.0017), Co-expression of E-cadherin and vimentin in the metastatic lymph nodes also showed worst DFS and OS (p=0.12 and p=0.027). Conclusions: Co-expression of E-cadherin and vimentin seems to be associated with the most aggressive phenotype and poorest prognosis in breast cancer, and positive E-cadherin expression may not always play roles for tumor suppression.

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臓器別:乳腺

手法別:トランスレーショナルリサーチ

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