演題抄録

基調講演

開催概要
開催回
第52回・2014年・横浜
 

Secretoglobin (SCGB) 3A2 is a novel anti-tumor agent

演題番号 : KL8-1

[筆頭演者]
Kimura Shioko:1 

1:Endocrinology Section, Laboratory of Metabolism, National Cancer Institute, U.S.A.

 

SCGB3A2, a member of the SCGB gene superfamily, consists of cytokine-like secreted proteins of small molecular weight (~10 kDa). SCGB3A2 is predominantly expressed in lung airways and exhibits growth factor, anti-inflammatory, and anti-fibrotic activities. SCGB3A2 was recently demonstrated to have anti-tumor activity using the Lewis Lung Carcinoma cells (LLC) lung metastasis model mouse, in which LLC cells were injected through the tail vein. When mice received daily intravenous administration of SCGB3A2 for 6 days starting right after LLC injection, followed by necropsy on day 21, they showed a markedly reduced number and size of pulmonary surface tumors as compared to PBS-injected control. Further, Scgb3a2-null mice when subjected to LLC lung metastasis model, developed considerably more pulmonary surface tumors. Taken together, these results revealed that SCGB3A2 exhibits anti-tumor activity. To begin to understand the mechanism and this effect of SCGB3A2 on metastasis, LLC cells were first subjected to proliferation, migration, and invasion assays in vitro with and without the addition of SCGB3A2 in the media. Additional experiments are under way to determine in more detail, the mechanism for the anti-tumor activity of SCGB3A2.

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